Vincenzo Parisi-Personal Web-Site

Curriculum Vitae: English version

Vincenzo Maria Franco Parisi, MD,

Born in Vibo Valentia on 08/21/1962

Current Position: Head of the Department of  Neurophysiology of Vision and Neurophthalmology Fondazione GB Bietti-IRCCS

Certified Full Professor of Ophthalmology

Studies and Training:

- High-school Diploma, Scientific lyceum in 1980 with 60/60; BA Medical Sciences graduated at the University of Rome "La Sapienza" on 03/11/1986 with 110/110 cum laude,

- Certification in Ophthalmology at the University of Rome "Tor Vergata" on 11/07/90 with the vote of 50/50 cum laude,

- From September 1989 to December 1991 he worked at the CNR, Institute of Neurophysiology in Pisa directed by Prof. Maffei, carrying out research on the role of Nerve Growth Factor in plasticity of the visual system.

Previous work positions and professional experience:

- Since 1985, scientific collaboration with: 1) Ophthalmology Clinic of the University of Rome "La Sapienza", 2) II Clinical Neurology, , University of Rome "La Sapienza", under the direction of Prof. Francesco Pierelli  and under the direction of Prof. Paolo Maria Rossini. Research topic: "neurophysiological study of the visual pathways in normal and pathological conditions ".

- Since November 1986, scientific collaboration and consultant at the Medical-Legal Institute (IML) of the Air Force in Rome in collaboration with Profs. Paolo Rizzo, Francesco Pierelli and Paolo Maria Rossini. Research topic: "Visual evoked potentials after photostress". In the same period, he began working with Prof. Massimo G. Bucci. These collaborations led to the first important publications on Clinical Vision Science (1991) and of Investigative Ophthalmology and Visual Science (1992).

- In September 1989 he attended the Institute of Neurophysiology at the CNR in Pisa directed by Prof. Lamberto Maffei (current President of the National Academy of the Lincei). In 1991, he won a scholarship to the CNR "Research in the field of disciplines related to the National Committee for technological research and innovation". Research topic "Role of Nerve Growth Factor in plasticity of the visual system". The results of this research have been published on Journal of Neuroscience (1992), Neuroscience (1992) and Proceedings Royal Society (1993)

- In 1992, clinical and research fellow at the Ophthalmology Clinic of the University of Tor Vergata, directed by Prof. Massimo G. Bucci.

- In 1993, clinical and research fellow at the Fatebenefratelli Association for Research (AFAR), Rome, and at the Columbus Integrated Complex of Rome, Ophthalmology Clinic of University of Tor Vergata. Research topic: “Physiopathology of retinal and visual pathway in patients affected from diabetes” in collaboration with the Department of Diabetology, University of Rome "Tor Vergata". He was the first in the international literature to sort out a primary dysfunction of retinal ganglion cells and in particular of those macular, at the onset of insulin-dependent diabetes. Such research works have been published on Graefe's Archive (1994 and 1995), Diabetologia (1997), EEG Journal (1997, 1998), Diabetes Metabolism Research and Review (2001)

- 1999-2002, Research grants from AFaR.

- From 1994 to 2002, Prof. Massimo G. Bucci, Director of the Ophthalmology Clinic of the University of Rome Tor Vergata, designated him to take care of the Department of Neurophysiology and Neurophthalmology. The latter cooperated with the Glaucoma Center of the same Clinic by studying the neurophysiopathology of glaucoma and morpho-functional correlations (OCT in relation to PERG and VEP) in ocular hypertension and glaucoma. The results of these studies have been published in leading journals such as Ophthalmology (1999, 2001, 2006) and Investigative Ophthalmology and Visual Science (1999).

- In the international literature, he was the first to highlight a post-retinal dysfunction due to phenomena of degeneration at the level of the lateral geniculate nucleus (Greafe's Archives, 1997, Clinical Neurophysiology 2001) and to document the effect of " enhancement" of the ganglion cells function and of  the neural conduction along the visual pathway through the use of Nicergoline (Pharmacological Research, 1999) or Citicoline (Ophthalmology, 1999; Doc Ophthalmol, 2005; Prog Brian Res, 2008). The study about the effects of Citicoline in glaucoma won the 1998 Award of Clinical Research of the Italian Society of Ophthalmology.

- Since 1998, he collaborates with the II Neurology Clinic, University of Rome "La Sapienza" and the Neurological Clinic of the University of Rome "Tor Vergata". Research topic: “The neurofunctional changes of the visual system in patients with multiple sclerosis, Alzheimer's disease, CADASIL, cerebrovascular diseases with involvement of the optic nerves, and migraine with and without visual aura.

- In the international literature, is was the first to suggest the use of OCT and pattern ERG for the “in vivo” evaluation of neurodegenerative processes of the retina that may be present in diseases such as Multiple Sclerosis, Alzheimer’s disease or CADASIL. Such research works have been published on Investigative Ophthalmology and Visual Science (1999), Clinical Neurophysiology (2001), Neurology (2003), Eur J Neurology (2008), Multiple Sclerosis (2011).

- In 1998, he began his collaboration with the Foundation for the Study and Research in Ophthalmology GB Bietti- ONLUS, under the supervision of Prof. Mario Stirpe (Chairman) and Prof. Massimo G. Bucci (Scientific Director).
He began working with the Retina Surgery Unit (Head Prof. Mario Stirpe) studying the physiopathological conditions of the vitreoretinal interface (particularly in myopic eyes), the various aspects of different surgical approaches and their related complications. The results of this research have been published on Ophthalmology (2001, 2003, 2004, 2005, 2007, 2008) and on Retina (2007, 2012).
In the same period he started working with the Unit of Medical Retina that had as research topic: “the physiopathology of various types of maculopathies (eg DMLE, myopic maculopathy) and any therapeutic implications (see Carotenoids or PDT). The results of this research have been published on Retina (2002, 2007), Investigative Ophthalmology and Visual Science (2005) and Ophthalmology (2008).
- Since 2001, the GB Bietti Foundation gave him the role of "Editor" (Head of research activity evaluation having as their main purpose the publication on international journals).

- Since 2005, the year of the acknowledgement of the GB Bietti Foundation as Institute of Hospital and Care with Scientific purpose (IRCCS), he become a member of the Scientific Committee, he was in charge of the "Ricerca finalizzata" and become Head of the department of "Neurophysiology of Vision and Neurophthalmology".
 

Under his responsibility, the department has produced, in the period 2005- august 2021, more than 200 publications in peer-reviewed journals and has played a unique and qualified clinical activities (before at the Biomedical Campus of Rome and actually at the Ospedale Britannico, Rome), delivering an average of 600 neuro-ophthalmological visits per year.

- 1999- 2010: he takes the responsibility of Teaching “Neurophthalmology” at the II School in Neurology at the Roma La Sapienza University, Rome, Italy

- 2002-2010: Professor of Neurophthalmology at the School of Specialization in Neurology at the Roma Tor Vergata University, Rome, Italy)

- 2005-current Ophthalmologist and full time clinical senior researcher at the Neurophysiology and Neurophthalmology Clinician and Research Unit, IRCCS Fondazione “G.B. Bietti”, Rome, Italy; principal clinician of the Neurophtalmology, Visual Neurophysiology and Visual Elactrophysiology ambulatory.

2018-2021 Teaching at Master I and II Level in Legal Medicine, at the Roma La Sapienza University, Rome, Italy)

Principal Investigator in Institutional Research Projects

- 2005-2007, Principal Investigator of the Project of the Ministry of Health “Ricerca Finalizzata”, with the topic: "Potential therapeutic role of Nerve Growth Factor in glaucoma: studies in animal models and humans." This project, lasting 36 months, was completed in 2009 and resulted in qualified scientific papers published on PNAS (2009), Vision Research (2009), Journal of Glaucoma (2011).

- 2007-2010, Principal Investigator of the Project of the Ministry of Health “Ricerca Finalizzata”, with the topic: "Leber’s optic neuropathy: from the early diagnosis to the rehabilitation". This project, lasting 36 months, was completed in 2009 and resulted in qualified scientific papers published on European Journal of Ophthalmology (2012)  and Investigative Ophthalmology and Visual Science Vision Research (2013).

- 2012, Principal Investigator of the AIFA project entitled "Evaluation of potential neuroprotective action of minocycline in addition to topical hypotonic therapy for the maintenance of functional impairment of vision in patients with Glaucoma"

- 2014, Principal Investigator of the Project of the Ministry of Health “Ricerca Finalizzata”, with the topic: " Morphofunctional visual pathways evaluation in multiple sclerosis: possible identification of neurodegenerative biomarkers".

- 2024--- Scientific Coordinator of Research Unit of the Project Funded by the MEF PNRR "Assessing central neuromodulation effects on immune-mediated synaptic dysfunction in progressive multiple sclerosis”

Principal Investigator in Clinical Trials

1996-1998, Principal Investigator of the No-profit clinical study “Evaluation of the effects of  Citicoline intramuscularly administered on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients=

1996-1998, Principal Investigator of the No-profit clinical study. “Evaluation of the effects of Nicergoline on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients.

2000-2002, Principal Investigator of the No-profit clinical study. “Comparison of the effects of  Citicoline intramuscularly administered and orally adimisted on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients.

2006-2007, Principal Investigator of the No-profit clinical study. “Evaluation of the effects of epigallocatechin gallate on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”.

2008-2012, Principal Investigator of the No-profit clinical study. “Evaluation of the effects of Coezime Q10 on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”.

2009-2013, Principal Investigator of sponsorized study “Evaluation of the effects of oral administration of L-acetil carnitine on the visual function in patients affected by Leber Hereditary Optic Neuropathy”

2013, Principal Investigator of sponsorized study “LHON Historical Case Record Survey”

2012-2014, Principal Investigator of No-profit clinical study. “Evaluation of the potential neuroprotective action of Citicoline added to the topic hypotonic therapy for the maintenance or amelioration of the visual functional deficit in patients affected by glaucoma”

2017-2019,  Principal Investigator of No-profit clinical study. Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases.

2017-2019,  Principal Investigator of No-profit clinical study. “Evaluation of the potential neuroprotective action of Citicoline in liposomial formulation added to the topic hypotonic therapy for the maintenance or amelioration of the visual functional deficit in patients affected by glaucoma”

2018-2019,  Co-Principal Investigator of sponsorized study “Evaluation of the effects of MACUPREV® on the visual function in patients affected by age-ralted maculopathy

2021- Principal Investigator of No-profit clinical study. "Multimodal Morpho-functional Study in Glaucoma Patients-Citicoline Oral Solution"

Associate Investigator in Clinical Trials

2013, Associated investigator, Clinical study by DOMPE’ NGF0113 “A 24 week phase Ib/II, multicenter, randomized, double-masked, vehicle controlled, parallel group, dose ranging study with a 24 week follow-up period to evaluate the safety and potential efficacy of two doses (60 and 180 ug/ml) of recombinant human nerve growth factor (rhNGF) eye drops solution versus vehicle in patients with typical retinitis pigmentosa (RP)”. The study was about the topical administration of rhNGF (recombinant human nerve growth factor) drops in a orphan disease called retinitis pigmentosa.

2014-2015 renovated with no funds up to 2021 Associated investigator of the study “Clinical and functional characterization of rare ocular diseases genetically transmitted”. 5x1000 grant Fondazione Bietti. (2011).

2016, Associated investigator of the observational study “Functional evaluation of retinal changes for post-neuritic degenerative processes in patients affected by multiple sclerosis” 5x1000 grant Fondazione Bietti. (2013).                                                         

 Scientific Activities

- He personally presented 219 communications at national congresses and 104 at International Congresses.

- He is author of 343 scientific publications including 203 on international journals (198 with Impact Factor)

 Total Impact Factor: 685.5; Personal H-index: 59 (Google Scholar), 49 (Scopus)
 
Total Normalized Impact Factor*: 908.9

Scientific Publications on Peer-reviewed Journals:

Recognition and Awards:

- In 1991 he won a scholarship from the National Research Council for "research in the field of disciplines related to the National Committee for technological research and innovation."

- In December 1993 he won a scholarship from the International Foundation Fatebenefratelli for "research in the field of retinal pathophysiology."

- In January 1998, his biography was published in WHO'S WHO IN SCIENCE AND ENGINEERING with the following reason "demonstrated considerable knowledge and appreciation recognized in their field of scientific application that contributed significantly to the improvement of society"

- In 1998 he won the Prize of the Italian Society of Ophthalmology for Clinical Research

- In 1999 and 2000, 2001 and 2002 and 2003 he won scholarships to the International Foundation Fatebenefratelli "Electrophysiology of Vision" and "Vision".
 
- In 2007, 2008 and 2010 he was appointed by the Association for Research in Vision and Ophthalmology (ARVO) "moderator" for the "Morphology, Electrophysiology and Visual Function"

- 2022 Awarded by the Prize of the “Italian Association for the fight against Ataxic Syndromes” with the research project “Identification of retinal morpho-functional involvement in patients with Friedreich's ataxia (FA) at early age and in adulthood”

Teaching:

- From 1999 to 2010: he takes the responsibility of Teaching “Neurophthalmology” at the II School in Neurology at the University of Rome La Sapienza
- From 2002 to 2010 Professor of Neurophthalmology at the School of Specialization in Neurology at the University of Rome "Tor Vergata".

- 2018-2021 Teaching at Master I  Level in Legal Medicine at the Roma La Sapienza University, Rome, Italy

Actually, Teacher at the School of Specialization in Neurology at the University of Rome "Campus Biomedico".

- “Expert reviewer” of:

Investigative Ophthalmology and  Visual Science,

Brain,

Ophthalmology,

Archive’s of Ophthalmology,

British Journal of Ophthalmology,

Vision Research,

Clinical  Neurophysiology,

European Journal of Neurology,

Documenta Ophthalmologica,

Ophthalmic and Physiological Optics,

Current Eye Research, 

European Journal of Ophthalmology,

Ottica Fisiopatologica.

Expert Review of Ophthalmology.

Journal of Translational Medicine

Journal of Neuro-ophthlamology

Experimental Eye Research

Journal of Glaucoma

 Journal of Alzheimer's Disease

Ophthalmology@Point of Care

Scientific Report

Frontiers Nurology

Editorial Board Member of Journal of Clinical Medicine