Vincenzo Parisi-Personal Web-Site

Curriculum Vitae: English version

Vincenzo Maria Franco Parisi, MD,

Born in Vibo Valentia on 08/21/1962
 

Current Posistion

Director of the "Clinical and Research center of neuro-ophthalmology, genetic and rare diseases" of the IRCCS G.B. Bietti Foundation, Britannico Hospital, Via di Santo Stefano Rotondo 6, Rome

Head of the Research Unit "Neurophysiology of Vision and Neuro-ophthalmology" of the IRCCS  B. Bietti Foundation, Britannico Hospital, Via di Santo Stefano Rotondo 6, Rome

National Scientific qualification as full professor in the Italian higher education system, in the call 2018/2020 (Ministerial Decree n. 2175/2018 ) for the disciplinary field of 06/F2 Ophthalmology. (Academic Recruitment Field 06/F - Integrated clinical surgery, according to the national classification). The validity of the qualification is twelve years, starting from the 09 November 2020 and will expire on the 09 November 2032

Studies and Training:

High-school Diploma, Scientific lyceum in 1980 with 60/60;

Medical Sciences Degree at the University of Rome "La Sapienza" on 03 november1986 with 110/110 cum laude,

Residency in Ophthalmology at the University of Rome "Tor Vergata" on 11 July 1990 with 50/50 cum laude,

From September 1989 to January 1991 he was trained at the CNR, Institute of Neurophysiology in Pisa by  Prof. Maffei, carrying out research on the role of Nerve Growth Factor on plasticity of the visual system.

Previous work positions:

1. From 1 February 1991 to 31 January 1992, he was granted a CNR scholarship at the Institute of Neurophysiology of the CNR in Pisa

2. 1993. Annual Fellow for "Research in the field of retinal pathophysiology" of the International Association of Fatebenefratelli for Research

3. 1999. Annual Fellow for "Electrophysiology of Vision" and "Vision" of the International Association of Fatebenefratelli for Research

4. 2000, 2001, 2002. Fellow for "Electrophysiology of Vision" and "Vision" of the International Association of Fatebenefratelli for Research

5. Since 2005, the year of the recognition of the G.B. Bietti Foundation as Institute of Hospitalization and Care of a Scientific Character (IRCCS), to date, he is a member of the Scientific Committee and is the Head of the Research Unit  "Neurophysiology of Vision and Neuro-ophthalmology" (Ministry of Health: Line 4)

6. From 1 October 2019 to 15 October 2022: Acting Head of the Ophthalmology Complex Unit of the IRCCS G.B. Bietti Foundation, Britannico Hospital, Via di Santo Stefano Rotondo 6, Rome

7. From 15 October 2002 - present (Current Position): Director of the "CLINICAL AND RESEARCH CENTRE of NEURO-OPHTHALMOLOGY, GENETIC AND RARE DISEASES" of the IRCCS G.B. Bietti Foundation, Britannico Hospital, Via di Santo Stefano 6, Rome

 Scientific Activities

Since 1986, his research activity aimed to study of the physio-pathological mechanisms occurring in the visual nervous system that induce a visual loss in several ophthalmological or neurodegenerative diseases. 

Main Reseach topics
1. He studied the "Role of Nerve Growth Factor (NGF) in plasticity of the visual system". The results of this research have been published in Journal of Neuroscience (1992), Neuroscience (1992) and Proceedings Royal Society (1993)

2. He was the first, in the international literature, to suggest a primary dysfunction of retinal ganglion cells and of those located in the macula, at the onset of insulin-dependent diabetes. The main research works were published on Graefe's Archive (1994 and 1995), Diabetologia (1997), EEG Journal (1997, 1998), Diabetes Metabolism Research and Review (2001),

3. He studied the neuro-physiopathology and the morpho-functional correlations (OCT in relationship to Pattern Electroretinogram and Visual Evoked Potentials) in ocular hypertension and glaucoma.

He was the first to highlight an early dysfunction of retinal ganglion cells that may precede the onset of visual field defects and a post-retinal dysfunction due to phenomena of degeneration at the level of the lateral geniculate nucleus. The main research works were published on Greafe's Archives (1997) Investigative Ophthalmology and Visual Science (1999), Clinical Neurophysiology (2001), Ophthalmology (1999, 2001, 2006, Frontier Aging Neuroscience (2021).

4. He was the first, in the international literature, to document,  the effect of “enhancement" of the function of the ganglion cells and of the neural conduction along the visual pathway in patients with glaucoma through the treatment with Nicergoline (Pharmacological Research 1999), Citicoline (Ophthalmology 1999, Doc Ophthalmol, 2005, Progress Brian Research 2008, Advanced Therapy 2019, Pharmaceutical 2021) and NGF (PNAS 2009), in patients with non-arteritic ischemic optic neuropathy through the treatment with Citicoline (European Journal of Neurology 2008, PLoS One 2019)  and of macular cells in patients with Age-Related Maculopathy treated with Carotenoids  and Antioxidants (Ophthalmology 2008, Advanced Therapy 2019)

5. In the international literature, he was the first to suggest the use of OCT, Pattern Electroretinogram, multifocal Electroretinogram, multifocal Photopic Negative Response and Visual Evoked Potentials for the “in vivo” evaluation of neurodegenerative processes involving retinal and post-retinal structures in diseases such as Multiple Sclerosis (EEG Journal 1998, Investigative Ophthalmology and Visual Science 1999, Multiple Sclerosis 2011, Frontiers Neurology 2020, Journal Clinical Medicine 2020, Advanced Therapy 2021, Diagnostics 2022, Journal Clinical Medicine 2023), Alzheimer’s disease (Clinical Neurophysiology 2001, PLoS One 2015), CADASIL (Clinical Neurophysiology 2000, Neurology 2003, Eur J Neurology 2007, ) and Spinocerebellar or Friedreich's Ataxia (J Journal Clinical Medicine 2021, Diagnostics 2022)     

6. By combined functional (Pattern Electroretinogram, multifocal Electroretinogram, multifocal Photopic Negative Response and Visual Evoked Potentials recordings) and morphological (OCT) assessments, he has contributed, in multicenter studies, to the clarification of the neuro-physiopathological mechanisms that induce the vision loss in several pathologies involving the nervous visual system such as amblyopia (Invest Ophthalmol Vis Sci 2010, Acta Ophthalmologice 2017, Greafe's Archives 2017), ischemic optic neuropathy (Eur J Neurology 2008, Greafe's Archives 2017 and 2021, PLoS One 2019), Leber hereditary optic neuropathy (Eur J Ophthalmology 2012, Investigative Ophthalmology and Visual Science 2013, Greafe's Archives 2015, Br J Ophthalmololgy 2016, Scientific Reports 2016, Clin Exp Ophthalmology 2018, Ophthalmology 2019, Am J Ophthalmology 2022 and 2023) and Dominant Optic Atrophy (Ophthalmology 2010 and 2011, Am J Ophthalmology 2014, Mitochondrion 2017, Am J Ophthalmology 2024)

7. Particular attention has been paid to the study of the pathophysiology of visual system abnormalities in migraine through functional (VEP: results published in European Journal of Ophthalmology 2007, Journal of Headache and Pain 2015, Frontiers in Neurology 2018, Journal of Pain 2019, Cephalalgia 2024); blink reflex: results published in Cephalalgia 2015, Journal of Pain 2018, Journal of Clinical Medicine 2021, Cephalalgia 2022, Journal of Headache and Pain 2022), neuroimaging with methodological innovations (results published in Journal of Headache and Pain 2016, 2017 e 2018, 2022, Neurology 2016 e 2019, Cephalalgia 2015, 2018, e 2019, Neurological Sciences 2019, Journal of Neurology 2020, International Journal of Molecular Sciences 2022, Frontiers Human Neurosciences 2023, Journal of Headache and Pain 2016 e 2021, Cephalalgia 2018, Neurology 2016 e 2019, Cephalalgia 2019) and neuromodulation (results published in Cephalalgia 2015 and 2019, Journal of Headache and Pain 2016, Neurological Sciences 2018, Brain Stimulation 2019, Journal of Headache and Pain 2021) approaches.

He is the author of 347 scientific publications including 207 on peer-reviewed international journals

Total Impact Factor: 703.9 

Personal H-index: 61 (Google Scholar), 50 (Scopus)
 

Personal H-index: Scopus excluding self-citations of selected author: 48

Citations: 11315 (Google Scholar), 7765 (Scopus)

Citations Scopus excluding self-citations of selected author: 6997

Scientific Publications on Peer-reviewed Journals:

Principal Investigator in Institutional Research Projects (competitive)

1.      01-04-2006 to 31-03-2009. Principal Investigator of the Finalized Research project of the Ministry of Health "Potential therapeutic role of Nerve Growth Factor in glaucoma: studies in an animal model and in humans". The total funding received (including co-financing by the Fondazione Roma) was 800,000 Euros, of which 300,000 Euros financed by the Ministry of Health.

2.      29-11-2007 to 01-12-2009 . Principal Investigator of the Finalized Research project of the Ministry of Health "Visual impairment in Leber's hereditary optic neuropathy: from early diagnosis to rehabilitation". The total funding received (including co-financing by the RUs participating in the Project) was 954,543 Euros, of which 300,000 Euros financed by the Ministry of Health

3.      01-10-2011 to 01-10-2015. Principal Investigator of the Research Project funded by AIFA "Evaluation of the potential neuroprotective action of Minicycline in addition to topical hypotonic therapy for the maintenance of visual functional deficit in patients with glaucoma". The total funding received was 447,740 Euros.

4.      01/10/2013 to 30/19/2015. Principal Investigator of the 2011 year “5 per mille” funds from the IRCCS-Bietti Foundation (Euro 10,000) for  project entitled: "Clinical-functional characterization of genetically transmitted early-onset rare eye diseases. Genotype phenotype correlation". The total funding received was 10,000 Euros.

5.      09-10-2014 to 08-10-2017. Principal Investigator of the Finalized Research project of the Ministry of Health "Morphofunctional visual pathways evaluation in multiple sclerosis: possible identification of neurodegenerative biomarkers". The total funding received (including co-financing by the OUs involved) was 683,870 Euros, of which 341,870 Euros financed by the Ministry of Health.

6.      20/12/2015 to 20/12/2017. Principal Investigator of the 2013 year “5 per mille” funds from the IRCCS-Bietti Foundation (Euro 10,000) of the project entitled: "Functional evaluation of retinal involvement from post-neuritic neurodegenerative processes in patients with Multiple Sclerosis". The total funding received was 11,516.20 Euros.

7.      01/04/2021 to 30/03/2023 Principal Investigator of the 2019 year “5 per mille” funds from the IRCCS-Bietti Foundation (Euro 10,000) of the project entitled: "Modulation of neuronal connectivity along the optic pathways in glaucoma patients: multimodal morphofunctional study". The total funding received was 53,588.12 Euros.

8.      2022- current. Principal Investigator of the project of the “Italian Association for the fight against Ataxic Syndromes" with the research project "Identification of retinal morpho-functional involvement in patients with Friedreich's ataxia (FA) in early age and adulthood". The total funding received is  50,000 Euros

9.      2024- current. Scientific Coordinator of the Research Unit of the MEF-funded project PNRR "Evaluation of the effects of central neuromodulation on immune-mediated synaptic dysfunction in progressive multiple sclerosis" The total funding received is 1,000,000 Euros.

Principal Investigator in Clinical Trials

1.      1996-1998, Principal Investigator of the No-profit clinical study “Evaluation of the effects of  Citicoline intramuscularly administered on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”

2.      1996-1998, Principal Investigator of the No-profit clinical study. “Evaluation of the effects of Nicergoline on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”.

3.      2000-2002, Principal Investigator of the No-profit clinical study. “Comparison of the effects of  Citicoline intramuscularly administered and orally adimisted on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”.

4.      2006-2007, Principal Investigator of the No-profit clinical study. “Evaluation of the effects of epigallocatechin gallate on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”.

5.      2008-2012, Principal Investigator of the No-profit clinical study. “Evaluation of the effects of Coezime Q10 on the retinal function and on the neural conduction along the visual pathways in glaucomatous patients”.

6.      2009-2013, Principal Investigator of sponsorized study “Evaluation of the effects of oral administration of L-acetil carnitine on the visual function in patients affected by Leber Hereditary Optic Neuropathy”

7.      2013, Principal Investigator of sponsorized study “LHON Historical Case Record Survey”

8.      2012-2014, Principal Investigator of No-profit clinical study. “Evaluation of the potential neuroprotective action of Citicoline added to the topic hypotonic therapy for the maintenance or amelioration of the visual functional deficit in patients affected by glaucoma”.

9.      2017-2019, Principal Investigator of No-profit clinical study “Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases”.

10.   2017-2019, Principal Investigator of No-profit clinical study. “Evaluation of the potential neuroprotective action of Citicoline in liposomial formulation added to the topic hypotonic therapy for the maintenance or amelioration of the visual functional deficit in patients affected by glaucoma”

11.   2018-2019, Co-Principal Investigator of sponsorized study “Evaluation of the effects of MACUPREV® on the visual function in patients affected by age-related maculopathy”

12.   2021-current. Principal Investigator of No-profit clinical study. "Multimodal Morpho-functional Study in Glaucoma Patients-Citicoline Oral Solution"

Associate Investigator in Clinical Trials

1.      2013, Associate investigator, Clinical study by DOMPE’ NGF0113 “A 24 week phase Ib/II, multicenter, randomized, double-masked, vehicle controlled, parallel group, dose ranging study with a 24 week follow-up period to evaluate the safety and potential efficacy of two doses (60 and 180 ug/ml) of recombinant human nerve growth factor (rhNGF) eye drops solution versus vehicle in patients with typical retinitis pigmentosa (RP)”. The study was about the topical administration of rhNGF (recombinant human nerve growth factor) drops in an orphan disease called retinitis pigmentosa.

2.      2014-2015 renovated with no funds up to 2021 Associate investigator of the study “Clinical and functional characterization of rare ocular diseases genetically transmitted”. 5x1000 grant Fondazione Bietti. (2011).

3.      2016, Associate investigator of the observational study “Functional evaluation of retinal changes for post-neuritic degenerative processes in patients affected by multiple sclerosis” 5x1000 grant Fondazione Bietti. (2013).                                                         

4.      2019- 2021, Associate investigator of the observational study “Molecular basis of inherited retinal dystrophies of the retina and of the optic nerve”. 5x1000 grant Fondazione Bietti. (2019).

 Recognition and Awards:

1. In 1991, he won a scholarship from the National Research Council for "research in the field of disciplines related to the National Committee for technological research and innovation."

2. In December 1993, he won a scholarship from the International Foundation Fatebenefratelli for "research in the field of retinal pathophysiology."

3. In January 1998, his biography was published in WHO'S WHO IN SCIENCE AND ENGINEERING with the following reason "demonstrated considerable knowledge and appreciation recognized in their field of scientific application that contributed significantly to the improvement of society".

4. In 1998, he was awarded by the Prize of the Italian Society of Ophthalmology for Clinical Research

5. In 1999 and 2000, 2001 and 2002 and 2003 he won scholarships to the International Foundation Fatebenefratelli "Electrophysiology of Vision" and "Vision".

 

6. In 2007, 2008 and 2010 he was appointed by the Association for Research in Vision and Ophthalmology (ARVO) "moderator" for the "Morphology, Electrophysiology and Visual Function"

7. 2022 Awarded by the Prize of the “Italian Association for the fight against Ataxic Syndromes” with the research project “Identification of retinal morpho-functional involvement in patients with Friedreich's ataxia (FA) at early age and in adulthood”

Teaching
1. From 1999 to 2010: he was assigned for teaching of “Neurophthalmology” at the II Residency School of Neurology at the University of Rome La Sapienza

 

2. From 2002 to 2010 Visiting Professor of  Neurophthalmology at the Residency School of Neurology at the University of Rome "Tor Vergata".

3. 2018-2021 Teaching at First Level Master in Legal Medicine at the Roma La Sapienza University, Rome, Italy

4.  From 30/11/2017 to 30/11/2020: Supervisor of  PhD Program in Molecular Medicine, curriculum in Neuroscience and Experimental Neurology. UNISR - Vita Salute San Raffaele University, Milan

5. From 30/11/2018 to 30/11/2021: Supervisor of PhD Program in Molecular Medicine curriculum in Neuroscience and Experimental Neurology. UNISR - Vita Salute San Raffaele University, Milan

6. 2022-current: he was assigned for teaching at the  Residency School of Neurology at the University of Rome "Campus Biomedico".

 Editorial Activity.

Editorial Board Member of Journal of Clinical Medicine

Reviewer ad hoc of:

Investigative Ophthalmology and  Visual Science,

Brain,

Ophthalmology,

Archive’s of Ophthalmology,

British Journal of Ophthalmology,

Vision Research,

Clinical  Neurophysiology,

European Journal of Neurology,

Documenta Ophthalmologica,

Ophthalmic and Physiological Optics,

Current Eye Research, 

European Journal of Ophthalmology,

Ottica Fisiopatologica.

Expert Review of Ophthalmology.

Journal of Translational Medicine

Journal of Neuro-ophthlamology

Experimental Eye Research

Journal of Glaucoma

 Journal of Alzheimer's Disease

Ophthalmology@Point of Care

Scientific Report

Frontiers Nurology

Member of the following Scientific Societies (past or current):

Societa' Oftalmologica Italiana

Società Italiana di Scienze Oftalmologiche

Società Italiana di Neurofisiologia Clinica Associazione Italiana Studio Glaucoma

Società Italiana di Neuroftalmologia

Società Italiana Retina

Società Italiana Perimetria e Diagnostica per Immagini

The Association for Research in Vision and Ophthalmology (ARVO)

New York Academy of Sciences

International Society for Clinical Electrophysiology of Vision (ISCEV)

Gruppo Interdisciplinare Neuroprotezione (Founder)